“Salol” redirects here. Salol may also refer to Salol, Minnesota.
3D model (Jmol)
Key: ZQBAKBUEJOMQEX-UHFFFAOYSA-N N
41.5 °C (106.7 °F; 314.6 K)
173 °C (343 °F; 446 K) at 12 mmHg
Solubility in water
1 g/6670 mL
Magnetic susceptibility (χ)
Refractive index (nD)
137.3 °C (279.1 °F; 410.4 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Phenyl salicylate, or salol, is a chemical substance, introduced in 1886 by Marceli Nencki of Basel. It can be created by heating salicylic acid with phenol. Once used in sunscreens, phenyl salicylate is now used in the manufacture of some polymers, lacquers, adhesives, waxes and polishes. It is also used frequently in school laboratory demonstrations on how cooling rates affect crystal size in igneous rocks.
In the salol reaction, phenyl salicylate reacts with o-toluidine in 1,2,4-trichlorobenzene at elevated temperatures to the corresponding amide o-Salicylotoluide. Salicylamides are one type of drug.
It has been used as an antiseptic based on the antibacterial activity upon hydrolysis in the small intestine.
It acts as a mild analgesic.
^ a b Merck Index, 11th Edition, 7282.
^ a b ChemBK Chemical Database http://www.chembk.com/en/chem/Phenyl%20salicylate
^ Allen, C. F. H.; VanAllan, J. (1946). “SALICYL-o-TOLUIDE” (PDF). Org. Synth. 26: 92. ; Coll. Vol., 3, p. 765